January 15th, 2008

Human pharmacokinetics of recombinant activated factor VII

Recombinant activated factor VII (rFVIIa, NovoSeven®; Novo Nordisk A/S, Bagsværd, Denmark) is established for the treatment of bleeding episodes and for the prevention of bleeding during surgery or invasive procedures in patients with congenital haemophilia A and B with inhibitors to coagulation factors VIII (FVIII) or IX (FIX) or in those expected to have a [...]

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December 31st, 1969

Phentolamine mesylate relaxes rabbit corpus cavernosum by a nonadrenergic noncholinergic mechanism

It is widely accepted that release of nitric oxide (NO) from nonadrenergic, noncholinergic nerves during sexual stimulation plays an important role in penile smooth muscle relaxation and erection. Sildenafil is the first orally active drug approved by the food and drug administration to treat male erectile dysfunction. Sildenafil inhibits cGMP specific type 5 phosphodiesterase, the [...]

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