April 6th, 2008
Cyclosporin A (CSA) is a uniquely potent immunosuppressant used world-wide to sustain organ transplantation. It has also been proven effective in a variety of autoimmune and related disorders. However, dose-dependent side-effects, particularly at the level of the kidney, may ultimately define the limits of clinical utility of the drug because they frequently mandate modification of [...]
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January 15th, 2008
In Canada, chronic obstructive pulmonary disease (COPD) affects 4.3% of adults aged â¥35 years, making it the fourth most common cause of illness and death. Worldwide, COPD is also the fourth leading cause of death and the 12th leading cause of disability. Acute exacerbations are the most frequent cause of hospital admissions and death among [...]
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January 15th, 2008
There are more than 4000 chemicals found in cigarette smoke. Cigarette smoking is associated with an increased incidence of both respiratory and cardiovascular disease, but the relationship of specific constituents with disease has not yet been established. Carbon monoxide (CO) is one of the cigarette smoke constituents that has a very high affinity for haemoglobin [...]
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January 15th, 2008
Reactive oxygen species (ROS), like superoxide anion (O2.â) and hydrogen peroxide (H2O2), play an important role in health and disease. They have been implicated in the pathophysiology of different disease states, including anthracyclin-induced cardiotoxicity (AIC), inflammatory bowel disease, ischaemia/reperfusion injury and neurodegenerative conditions. The hypothesis is that in these pathological conditions, relatively large amounts of [...]
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