January 15th, 2008

Use of hormone replacement therapy and risk of fracture

Menopause is accompanied by accelerated bone loss, and increasing incidence of fractures. Several studies have shown that hormone replacement therapy (HRT) can reduce bone loss, increase bone mineral density, and decrease the risk of fracture. However, the duration of treatment needed and of the protective effect after treatment is stopped, and the influence of age [...]

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January 15th, 2008

Toxicity difference can exist between bioequivalent carbamazepine tablets.

Carbamazepine (CBZ) is considered as the primary drug for the treatment of partial and tonic-clonic seizures. It is also the drug of choice for trigeminal neuralgia and frequently used for treating bipolar depression. The originator patent expired long ago (in 1986) and there are now several generic alternatives. However, after the introduction of the generic [...]

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